8:00 am Coffee & Networking

Strategy – Selection – Characterization

8:30 am Providing Translational Support for TSR Programs

  • Geeta Sharma Scientific Fellow, Translational Research, Tesaro

8:55 am Models to Understand the Mechanisms of Action of Cancer Biologic Therapies

  • Dan Powell Director, Clinical Tumor Tissue Facility & Associate Professor , University of Pennsylvania

9:20 am Immunoprofiling of Murine Tumor Models to Improve the Translational Prediction of Immune-Based Therapeutics

9:45 am Q&A Panel – Strategy – Selection – Characterization

  • Geeta Sharma Scientific Fellow, Translational Research, Tesaro
  • Dan Powell Director, Clinical Tumor Tissue Facility & Associate Professor , University of Pennsylvania

10:15 am Morning Refreshments

Precision Gene Editing for Disease Modelling and Target Validation

11.05 Applications of Next Generation Genetic Engineering Approaches

Andrew Rhim, Associate Director - Translational Research & Assistant Professor – Gastroenterology, MD Anderson Cancer Center


11.30 Transgenic Manipulation of Tumor Organoids for “Personalized” Modeling of Diverse Tumor Subtypes

Joshua Breunig, Assistant Professor, Cedars-Sinai Medical Center


11.55 Using 3D Tumor Models to Investigate the Role of Immune Cells on the CSC Niche

Esmaiel Jabbari, Professor, University of South Carolina


12.20 Q&A Panel - Precision Gene Editing For Disease Modelling & Target Validation

Andrew Rhim, Associate Director - Translational Research & Assistant Professor – Gastroenterology, MD Anderson Cancer Center

Joshua Breunig, Assistant Professor, Cedars-Sinai Medical Center

Esmaiel Jabbari, Professor, University of South Carolina

Models and Strategies to Bridge the Combination Gap

12:40 pm Lunch

1:40 pm Round Table Discussions

2:30 pm Moderator Feedback Panel

2:40 pm Afternoon Refreshments

Models Aiding Dose Translation and Understanding Drug Response

3:10 pm Challenges & Opportunities in Understanding Drug Exposure at The Site Of Action Within Pre-Clinical Tumor Models And The Potential Implications Of Transporter Mediated Efflux

3:35 pm NCI’s Patient Derived Models Repository Quality Control and Preclinical Efforts

  • Yvonne Evrard Operations Manager , National Institute of Health Sciences

4:00 pm Q&A Panel – Models Aiding Dose Translation and Understanding Drug Response

  • Rhys Jones Senior Director DMPK , Pfizer
  • Yvonne Evrard Operations Manager , National Institute of Health Sciences

4:20 pm Close of Conference