Developing Murine Tumor Models for the Preclinical Evaluation of Bispecific Antibodies & Cell Therapies
- Building a strategic tumor model cascade across in vitro and humanized in vivo systems and discussing the predictive value of these models
- Leveraging genetically engineered mouse models to capture human relevant microenvironmental barriers, revealing resistance mechanisms that standard NSG/xenograft models fail to replicate
- Combining cross model insights to overcome durability, trafficking and translational challenges, enabling smarter molecule optimization, clearer responder profiling and more confident progression of next generation bispecifics