Exploring Tumor Localized CD137 Agonism with Bicycle Tumor-Targeted Immune Cell Agonists (Bicycle TICAs®)

Time: 12:15 pm
day: Translation Track - Day 1 am


  • Description of the development of tumor-targeted immune cell agonists (Bicycle TICA™) based on constrained bicyclic peptides (Bicycles®) to activate costimulatory receptors selectively in the presence of tumor cells
  • Outlining the preclinical mechanistic data underlying the profound reprogramming of the tumor immune microenvironment
  • Highlighting translational aspects of work to inform clinical trials