Modelling Small Cell Lung Cancer in Preclinical Development of Synthetic Oncolytic Virus

Time: 8:30 am
day: Day Two


  • Tumor heterogeneity of small cell lung cancer tumors is challenging to recapitulate in a single preclinical model
  • To better model the complexity of SCLC tumor and microenvironment and to improve translation of preclinical findings into clinic Oncorus employed a number of models including cell- and patient- derived tumor xenografts, GEMMs and
    humanized mouse tumor models
  • Based on in vitro studies of the replication of oncolytic virus, sensitive models were identified, and successfully implemented in vivo identifying treatmentresponsive PDXs