Combination of a Multimeric Anti-DR5 IgM Antibody with Targeted Agents Induces Synergistic Tumor Cytotoxicity in Vitro & in Vivo

Time: 8:00 am
day: Day One


  •  Death receptor 5 (DR5) is activated upon receptor trimerization and induces cell death. IGM-8444 is a multivalent IgM antibody that efficiently clusters DR5 to induce potency tumor cytotoxicity
  • IGM-8444 has a good preclinical safety profile, enabling opportunities for rational combinations with targeted agents
  • Synergistic combinations were identified in vitr