Combination of a Multimeric Anti-DR5 IgM Antibody with Targeted Agents Induces Synergistic Tumor Cytotoxicity in Vitro & in Vivo
Time: 8:00 am
day: Day One
Details:
- Death receptor 5 (DR5) is activated upon receptor trimerization and induces cell death. IGM-8444 is a multivalent IgM antibody that efficiently clusters DR5 to induce potency tumor cytotoxicity
- IGM-8444 has a good preclinical safety profile, enabling opportunities for rational combinations with targeted agents
- Synergistic combinations were identified in vitr
