Translating Preclinical Combinatorial Therapy Approaches in In Vitro & In Vivo Models of Human Glioblastoma Multiforme

Time: 10:00 am
day: Day Two


  • Identification of potentially efficacious agents via NCI drug library and drug-gene network analysis using GBM spheroids developed from primary patient tissue
  • Are single agent and combinatorial effect predictions correct when tested in an in vitro setting?
  • Will in vitro single and combination agent efficacy data translate into in vivo pharmacology models?
  • Does reverse translation of in vivo PDX tumors recapitulate prior in vitro results?