TissueSpec® Bone, Liver & Lung dECM Hydrogels for Modeling Organotropic Breast Cancer Metastasis
- Detailing the generation, optimization, and validation of tissue-specific dECM hydrogels to establish biologically relevant platforms that recapitulate key features of bone, liver, and, lung microenvironments
- Demonstrating that dECM hydrogels modeling key metastatic secondary organs (Bone, Liver and Lung; TissueSpec®) induce distinct transcriptional states in patient-derived breast cancer organoids, revealing metastatic niche-adapted tumor phenotypes that standard basement membrane matrix fails to capture
- Highlighting how tissue-specific 3D models enable more predictive drug testing and biomarker discovery in metastasisrelevant applications