Beatrice Wang

Beatrice Wang

Company: IGM Biosciences

Job title: Associate Director


Combination of a Multimeric Anti-DR5 IgM Antibody with Targeted Agents Induces Synergistic Tumor Cytotoxicity in Vitro & in Vivo 8:00 am

 Death receptor 5 (DR5) is activated upon receptor trimerization and induces cell death. IGM-8444 is a multivalent IgM antibody that efficiently clusters DR5 to induce potency tumor cytotoxicity IGM-8444 has a good preclinical safety profile, enabling opportunities for rational combinations with targeted agents Synergistic combinations were identified in vitrRead more

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