Eshita Khera
Principal Scientist Novartis
Seminars
Wednesday 29th July 2026
Applying QSP & PBPK Modelling to Empower Translational Drug Development for Biologic Degraders
12:00 pm
- Empowering translational confidence by generating trustworthy assay data and ensuring these inputs are robust enough to feed mechanistic and quantitative systems pharmacology (QSP) models
- Tactics to overcome uncertainty across diverse mouse models, each with unique feedback loops, resistance mechanisms and pathway wiring, by categorizing models (high-bar, low-bar, phenotype-specific) and identifying which biological features best map to the intended patient population
- Aligning on dose selection frameworks, leveraging modern models to support dose optimization, shorten trial timelines and improve the likelihood of selecting dosing strategies that deliver meaningful benefit earlier in development
