CONFERENCE DAY ONE - TUESDAY JULY 22, 2025

8:00 am Check-In, Badge Collection & Morning Coffee

8:50 am Chair’s Opening Remarks

  • Hongyu Xue Director - In Vivo Pharmacology & Oncology Research, Bayer

Building a Consensus on Modeling Protocols to Empower Translation to the Clinic

9:00 am Syngeneic Models to Support Bispecific T Cell Engager Drug Development

  • Sarah OBrien Senior Principal Scientist, Boehringer Ingelheim

Synopsis

  • Model development to recapitulate the target expression and the tumor microenvironment
  • Uncovering strategies for combination treatments
  • Understanding mechanisms of treatment resistance

9:30 am Session Reserved for Certis Oncology

  • Michael Boice, PhD Senior Director, Scientific Engagement and Key Accounts, Certis Oncology

Synopsis

  • Presentation details to be announced

10:00 am Generation & Characterization of a Post-Checkpoint Inhibitor Mouse Tumor Model of Resistance

Synopsis

  • Mouse models that mimic the patient population in the clinic who have acquired resistance to checkpoint therapies
  • Combination efficacy of our clinical assets in the IO refractory tumor models
  • Leveraging these findings to improve translation to benefit Post-CPI patients

10:30 am Session Reserved for Champions Oncology

Synopsis

  • Presentation details to be announced

11:00 am Morning Break & Speed Networking

Synopsis

As the tumor modeling community comes together once again, this session offers the perfect opportunity to reconnect with peers and forge new connections. Through a series of structured 3-5 minutes introductions, you'll be paired with fellow attendees, making it easy to expand your network and engage with industry colleagues!

Applications in Drug Discovery
& Screening

11:45 am Adaptable & Hemodynamic Human Endothelial Cells for Immunotherapeutic Organoid Tumor Targeting

Synopsis

  • Exploring the integration of multiple cell types, including immune cells and stromal cells, to create more physiologically relevant models
  • Discussing how this device can be implemented for drug screening purposes and to uncover the molecular basis of tumor resistance and metastasis
  • Showcasing a case study illustrating how this device provided critical insights into CAR-T development, and potential combination strategies

12:15 pm Pre-Lunch Pulse: What’s Challenging You Day-to-Day? Reflections on the Morning Sessions

Synopsis

Join us for an informal, open-floor conversation where attendees can share the real-world challenges they face in applying tumor models to drug discovery and development. This is a chance to reflect on insights from the morning sessions, exchange ideas, and connect with peers over shared experiences – just before we break for lunch. Whether you're here to listen or contribute, this relaxed session is designed to spark meaningful dialogue and set the tone for continued conversations over lunch.

12:45 pm Lunch Hosted by Element Biosciences

Synopsis

Invite only networking lunch with experts from Element Biosciences

Applications for Efficacy Evaluation & Biomarker Discovery

Synopsis

Track Moderator: Hongyu Xue, Director, In Vivo Pharmacology, Oncology Research, Bayer

11:45 am Mastermind Session:Discussing the Different in vitro, in vivo, ex vivo & in silico Models in Use

Synopsis

  • What models do you use, and in what context do you use them for?
  • What challenges have you encountered, and how have you overcome them?
  • What is the optimal number of preclinical models to accurately predict response in the clinic?

12:15 pm Screening Models for ADC Treatment

Synopsis

  • Multiple in vitro assays can be utilized to determine ADC binding kinetics, cytotoxicity, internalization, and bystander assays to determine which tumor model and which ADC is best suited to assess ADCs in an in vivo model
  • Efficacy in an in vivo model is an important step in assessing ADCs in a complex system

12:45 pm Lunch Break & Networking

1:25 pm Advancing Targeted Protein Degrader Identification Through Mathematical Models

Synopsis

  • Spotlighting the development and use of mathematical models and theories to empower targeted protein degradation development
  • Clarifying the interplay between different parameters responsible for modulating the pharmacodynamics response of TPDs
  • Discussing the findings from these models and theories to gain a deep and intuitive understanding of the mechanism by which PROTACs and glue binders induce targeted protein degradation

1:55 pm Genetically Engineered Mouse Models to Empower Diffuse Large B Cell Lymphoma Therapeutic Improvement

Synopsis

  • Whole exome sequencing in patients informs the generation of faithful mouse models to study DLBCL development and progression
  • Single cell RNA sequencing allows to study B-cell lymphomagenesis and the concomitant T-cell-mediated immune response
  • The combined analysis of asymptomatic animals at multiple time points and mice with lymphoma informs potential therapies for patients

1:25 pm Selection & Characterization of in vivo Models to Empower ADC Development & Decision-Making

  • Jutta Deckert Vice President, Research & Development, Iksuda Therapeutics

Synopsis

  • Discussing the challenges in choosing the right in vivo model that expresses the target of interest and matches the genetic profiles observed in the patient population
  • Highlighting the rationale behind selecting the right cell-derived or patient-derived model
  • Leveraging findings from models to inform decision-making

1:55 pm Advancing Cell Therapies Through Diverse Tumor Models

  • Rosa Ng Associate Director, Cell Therapy Innovation, Takeda

Synopsis

  • Challenges in evaluating allogeneic cell therapies preclinically
  • Rationale of selecting different tumor models to assess allogeneic cell therapies
  • Assessing strategies to improve infiltration and persistence in tumor microenvironment

2:25 pm Afternoon Networking Break & Refreshments

Employing Clinical Lessons Learned & Pitting Subcutaneous Against Orthotopic Models to Uncover Translational Relevance

3:00 pm Smarter Models, Faster Approval: Leveraging Mouse Clinical Trials to Accelerate Drug Development

Synopsis

  • Further presentation details to be announced

3:45 pm Patient-Derived Tumor Spheroids to Model the Tumor Microenvironment & Accelerate Drug Development

Synopsis

  • Applying patient-derived tumor spheroids to model the tumor immune microenvironment including T cell infiltration and function, tumor fibrosis, CAF and endothelial cell biology
  • Modeling the specific treatment response of compounds on the patient tumor immune environment and cancer epithelial cells using single cell RNASeq and proteomics
  • Understanding how patient-derived tumor spheroids accelerate drug development using liver and pancreatic cancer as examples

4:00 pm Novel Applications of Humanized Mouse Models in Immuno-Oncology: Drug Evaluation & Target Identification Methods

Synopsis

  • Using primed immune cells with cancer cells in co-inoculated models to overcome GVHD issues
  • In vivo efficacy testing using fresh patient samples to best recapitulate the tumor microenvironment
  • Target identification leveraging CRC (conditional reprogrammed cells) with fast in-vivo validation

4:30 pm Enhancing the Clinical Relevance of Brain Tumor Research Through Orthotopic Mouse Models

Synopsis

  • Reiterating the importance of using multiple models to get a holistic view on oncology research
  • Comparing subcutaneous versus orthotopic models to understand which model better replicates the tumor microenvironment
  • Exploring the predictive power of orthotopic models in evaluating therapeutic response to lead better translation to the clinic for glioblastoma and pediatric brain tumors

5:00 pm Chair’s Closing Remarks

  • Hongyu Xue Director - In Vivo Pharmacology & Oncology Research, Bayer

5:10 pm Drinks Reception