8:45 am

Registration & Virtual Morning Coffee Networking

9:00 am Chair’s Opening Remarks

Advances in Preclinical Oncology Model Utilization

9:10 am Organoids: A Revolutionary New Tool for Drug Screening

  • Rekha Pal Director - Scientific Engagement, Crown Bioscience

Synopsis

• Discover organoids as a more physiologically relevant 3D in vitro model
• Find out why HUB organoids are considered a best-in-class system
• Understand how organoids are revolutionizing oncology drug development
• Learn how patient-derived xenografts (PDX) can be leveraged to develop the largest organoid library for oncology drug discovery

9:40 am Leveraging Preclinical Mouse Models to Understand Cancer Cell Behavior at Secondary Sites & Quantify the Risk of Tumor Metastasis

Synopsis

• Understanding the nature of cancer heterogeneity and how this necessitates personalized therapies
• Conducting predictive analysis to determine tumor aggression and metastatic spread likelihood
• Utilizing multiple syngeneic mouse models to trace the fate of metastatic cells from the primary site to distant organs

10:00 am The Use of Humanized Mice for the Preclinical Evaluation of Bispecific Antibody Efficacy & Safety for Immune-Oncology Research

  • Dr. James Keck Senior Director, Innovation & Product Development, The Jackson Laboratory

Synopsis

• The addition of 3 human cytokines (GM-CSF, IL-3 & Kit Ligand) into the NSG mouse provide for a more robust myeloid compartment after humanization
• Showcase data on the myeloid engraftment kinetics and show checkpoint inhibitor efficacy against several PDX

10:30 am Live Q&A – Ask the Panel Your Burning Questions

11:15 am

Virtual Speed Networking

Synopsis

Recreating the face-to-face networking in the virtual world. We will pair you up with
fellow attendees to break the ice and make new business relationships!

11:50 am

Morning Break

• Live Demo in Virtual Exhibition Hall
• One-to-One Meetings

Dedicated Roundtable Discussion Chatroom:
• Using Patient Tissue Sample as an Effective Tool to
• Overcome Resistance and Translation Challenges

Preclinical Models for Drug Discovery From Drug Discovery to Target Validation

12.00 Identifying Predictive & Prognostic Biomarkers Through Preclinical Modeling of Syngeneic Tumors

Maryland Franklin, Executive Director, Scientific Development, Covance

12.30 Combination of a novel RAF/MEK inhibitor, CH5126766, with the FAK inhibitor defactinib for the treatment of KRAS mutant cancer

Silvia Coma, Associate Director, Verastem Oncology

12.50 Live Q&A - Ask Speakers Your Burning Questions

Preclinical Models for Drug Development From Tox to Safety Profiling

12.00 Development of Brain Metastasis Cancer Models from Heavily Treated Patients & Strategies

Kin-Hoe Chow, Associate Director of Center for Patient Derived Models, Dana Farber Cancer Institute

12.20 Overcoming Translational Barriers by using the SRG Rat: Case Studies with the OncoRat®

Fallon Noto, Director In Vivo & Oncology Services, Hera BioLabs

12.50 Live Q&A - Ask Speakers Your Burning Questions

1:15 pm Networking Lunch

• Live Demo in Virtual Exhibition Hall
• One-to-One Meetings

Dedicated Roundtable Discussion Chatroom:
• Understanding Metastatic Spread Throughout Different
Organs by Studying Patient Samples

Preclinical Models for Drug Discovery From Drug Discovery to Target Validation

2.00 In Vivo Efficacy & Toxicity Evaluation Using Various Humanized Mouse Models to Increase Clinical Translation

Qingcong Lin, CEO, Biocytogen Boston Corporation 

2.20 Assessment of Murine Colorectal Cancer by UHF Ultrasound Using 3D Reconstruction & Nonlinear Contrast Imaging

Jessica Freeling, Physiology Core Facility Director, The University of South Dakota

2.40 Live Q&A - Ask Speakers Your Burning Questions

Preclinical Models for Drug Development From Tox to Safety Profiling

2.00 SubQperior: A Superior Syngeneic Model System to Subcutaneous Tumor Models

Holger Weber, Head of In Vivo, Pharmacology, ProQinase

2.30 Adopting the Appropriate Model for Your Target Therapy

Sangeetha Palakurthi, Vice President, Elstar Therapeutic

2.50 Live Q&A - Ask Speakers Your Burning Questions

3:15 pm Afternoon Break & Poster Session

Harnessing Tumor Models to Overcome Low Translation Outside the Clinic

4:00 pm Assessment of Biologics’ Efficacy Using Preclinical Models Featuring Humanized Immune Checkpoint Models or Stem Cell-Reconstituted Immunodeficient Mice

  • Kader Thiam Vice President - Transgenic Technologies & Director - Business Development, GenOway

Synopsis

• Understanding the breakthrough of immunotherapy for the success of cancer therapy
• Exploring why there are subsets of patients, which do not show robust response to immunotherapy
• Navigating the limitations of immuno-oncology to ensure preclinical models recapitulate the complexity of the etiology of tumors
• Exploring how immune checkpoint models as well humanized as immunodeficient mice can be harnessed to interrogate and model anti-tumor immune response

4:30 pm Multidisciplinary Science Elucidates Drug Resistance in Cancer: Integration of Mathematics & Tumor Models

  • Aaron Goldman Instructor in Medicine and Associate Bioengineer, Harvard Medical School

Synopsis

• Methods to integrate the entirety of the tumor ecosystem to interrogate drug resistance
• Blending ex vivo and in vivo models with computational biology to understand how anti-cancer drugs drive tumor resistance
• Utilizing stochastic, deterministic, systems biology and game theory models to uncover novel biological behavior
• Validating mechanistic biology and confirming efficacy of novel drug combinations, in vivo

4:50 pm Live Q&A – Ask Our Speakers Your Burning Questions

5:20 pm Chair’s Closing Remarks

5:45 pm

Virtual Drinks Reception & Roundtable hosted by Crown Bioscience

  • Rekha Pal Director - Scientific Engagement, Crown Bioscience

Synopsis

Join Crown Bioscience’s virtual drinks reception and poster session to help you connect with your peers in a relaxed atmosphere. Continue scientific discussions following the day 1’s presentations and forge new relationships with your fellows.