7:45 am
Welcome Coffee & Registration
8:30 am Chair’s Opening Remarks
Advances in Preclinical Oncology Model Utilization
8:40 am Organoids: A Revolutionary New Tool for Drug Screening
Synopsis
• Discover organoids as a more physiologically relevant 3D in vitro model
• Find out why HUB organoids are considered a best-in-class system
• Understand how organoids are revolutionizing oncology drug development
• Learn how patient-derived xenografts (PDX) can be leveraged to develop the largest organoid library for oncology drug discovery
9:10 am Leveraging Preclinical Mouse Models to Understand Cancer Cell Behavior at Secondary Sites & Quantify the Risk of Tumor Metastasis
Synopsis
• Understanding the nature of cancer heterogeneity and how this necessitates personalized therapies
• Conducting predictive analysis to determine tumor aggression and metastatic spread likelihood
• Utilizing multiple syngeneic mouse models to trace the fate of metastatic cells from the primary site to distant organs
9:40 am Patient-Derived Tumor Xenografts in Humanized NSG-SGM3 Mice: A New Immuno-Oncology Platform
Synopsis
• The addition of 3 human cytokines (GM-CSF, IL-3 & Kit Ligand) into the NSG mouse provide for a more robust myeloid compartment after humanization
• Showcase data on the myeloid engraftment kinetics and show checkpoint inhibitor efficacy against several PDX
10:10 am
Speed Networking
Synopsis
This session is the ideal opportunity to get face-to-face time with many of the brightest minds working in the preclinical oncology field and establish meaningful business relationships to pursue for the rest of the conference.
10:40 am
Morning Break
Preclinical Models for Drug Discovery From Drug Discovery to Target Validation
11.15 Identifying Predictive & Prognostic Biomarkers Through Preclinical Modeling of Syngeneic Tumors
Maryland Franklin, Executive Director, Scientific Development, Covance
11.45 Combination of a novel RAF/MEK inhibitor, CH5126766, with the FAK inhibitor defactinib for the treatment of KRAS mutant cancer
Silvia Coma, Associate Director, Verastem Oncology
Preclinical Models for Drug Development From Tox to Safety Profiling
11.15 Characterization of Human Cancer Xenografts in Humanized Mice
Jonathan Rios-Doria, Associate Director, Incyte
12.00 Overcoming Translational Barriers by using the SRG Rat: Case Studies with the OncoRat®
Fallon Noto, Director In Vivo & Oncology Services, Hera BioLabs
12:15 pm Networking Lunch
Preclinical Models for Drug Discovery From Drug Discovery to Target Validation
1.15 High-Throughput Screening for Discovery of Drug Mechanisms
1.45 Modeling the Immune Suppressive Tumor Microenvironment In Vitro for Target Discovery
Silvia Goldoni, Principle Scientist, Novartis Institute for Biomedical Research
2.15 Assessment of Murine Colorectal Cancer by UHF Ultrasound Using 3D Reconstruction & Nonlinear Contrast Imaging
Jessica Freeling, Physiology Core Facility Director, The University of South Dakota
Preclinical Models for Drug Development From Tox to Safety Profiling
1.15 Development of Brain Metastasis Cancer Models from Heavily Treated Patients & Strategies
Kin-Hoe Chow, Associate Director of Center for Patient Derived Models, Dana Farber Cancer Institute
1.45 SubQperior: A Superior Syngeneic Model System to Subcutaneous Tumor Models
Holger Weber, Head of In Vivo, Pharmacology ProQuinase
2.00 Adopting the Appropriate Model for Your Target Therapy
Sangeetha Palakurthi, Vice President, Elstar Therapeutic
2:30 pm Afternoon Break & Poster Session
Harnessing Tumor Models to Overcome Low Translation Outside the Clinic
3:30 pm Assessment of Biologics’ Efficacy Using Preclinical Models Featuring Humanized Immune Checkpoint Models or Stem Cell-Reconstituted Immunodeficient Mice
Synopsis
• Understanding the breakthrough of immunotherapy for the success of cancer therapy
• Exploring why there are subsets of patients, which do not show robust response to immunotherapy
• Navigating the limitations of immuno-oncology to ensure preclinical models recapitulate the complexity of the etiology of tumors
• Exploring how immune checkpoint models as well humanized as immunodeficient mice can be harnessed to interrogate and model anti-tumor immune response
4:00 pm Multidisciplinary Science Elucidates Drug Resistance in Cancer: Integration of Mathematics & Tumor Models
Synopsis
• Methods to integrate the entirety of the tumor ecosystem to interrogate drug resistance
• Blending ex vivo and in vivo models with computational biology to understand how anti-cancer drugs drive tumor resistance
• Utilizing stochastic, deterministic, systems biology and game theory models to uncover novel biological behavior
• Validating mechanistic biology and confirming efficacy of novel drug combinations, in vivo
4:30 pm Roundtable Discussion: The Revolution of the Biobank – Increase Your Model Translational Success & Decrease the Need for Animal Testing Think Tank Roundtable Sessions
Synopsis
This practical and highly interactive breakout roundtable will join attendees to crowd-source solutions and share opinions around pre-assigned topic areas. A valuable chance for attendees to unite around hot topics and debate best practice. No more sitting quietly, this is a dedicated opportunity for you to voice your experiences and identify unique solutions.
5:20 pm Chair’s Closing Remarks
5:30 pm
Drinks Reception hosted by Crown Bioscience & Poster Session
Synopsis
Join Crown Bioscience’s drinks reception and poster session to help you connect with your peers in a relaxed atmosphere. Continue scientific discussions following the day 1’s presentations and forge new relationships with your fellows.