Workshop A Tuesday, July 16

11:30 am - 2:30 pm

Challenges, Insights & Future Directions for Experimental Models in Cancer Immunotherapy

Workshop Leader: Shiva Kazerounian, Associate Director, In Vivo Pharmacology Lead , BRG, LLC

Understanding tumor placement, immune composition, response to treatment, and molecular characterization for the model of interest can be invaluable when designing the most appropriate study for your research goals. However, major issues remain, not only in selecting and optimizing models and tools for cancer immunotherapy research, but in selecting who to work with and when. Discussions in this session will centre on:
  • The range of current IO models available amongst their strengths and weaknesses
  • Mouse syngeneic models, their genetic backgrounds and use in IO for mono or combination therapy
  • How to identify, select and work with model developers and CRO’s available
Shiva Kazerounian Berg Scienist Speaker photo

Shiva Kazerounian, Associate Director, In Vivo Pharmacology Lead , BRG, LLC

Workshop Cancelled Tuesday, July 16

Workshop C Tuesday, July 16

3:00 pm - 6:00 pm

Considerations in Modeling the Microenvironment

Workshop Leader: Esmaiel Jabbari, Professor , University of South Carolina

In the last few decades, cancer stem cells (CSC) have proven to play a key role in tumor initiation resistance and recurrence. Recent advances have also begun to elucidate the complex cross talk at different stages of tumor progression between the TME and CSC’s. This session aims to provide an insight into the role and importance of CSC’s in the context of the ME as well as examine the clinical implications of targeting these interactions.

Topics to be covered include:

  • Current state of the art for modeling the TME interactions in the context of the CSC niche.
  • The importance of CSC TME interactions alongside potential therapeutic targets for the development of more effective treatments against cancer
  • The significance of stromal cells, immune cells, extracellular matrix, tumor stiffness, and hypoxia in regulation of CSC plasticity and therapeutic resistance

Esmaiel Jabbari, Professor , University of South Carolina